Case = 12 facial tissue cubes (720 face tissue per case) Because cold and flu viruses are often spread by hand contact, Kleenex Brand has developed a tissue for your whole family This Kleenex Anti-Viral tissue is 3-ply for extra softness The specially treated middle layer helps kill cold and flu viruses in the tissue within 15 minutes Kleenex Anti-Viral tissue boxes are available in a variety of colors designs to accent different environments' decor - from schools to offices to commercial buildings